The Effects Of Spirulina platensis And Saccharomyces cerevisiae On The Distribution and Cytokine Production Of CD4+ And CD8+ T-Lymphocytes In Rabbits

The Effects Of Spirulina platensis And Saccharomyces cerevisiae On Cytokine Production

  • Nilay Seyidoglu Namik Kemal University, Veterinary Faculty, Physiology Department
  • Nurten Galip
  • Ferah Budak
  • Ender Uzabaci

Abstract

Natural additives have become one of the most alternative immune enhancer nowadays.  Especially, Spirulina platensis (SP) and Saccharomyces cerevisiae (SC) and their contents have been applied for improving the immune system and thereby life quality.  This study is purported to regulate the immune effect of S. cerevisiae and S. platensis combination. Forty, male New Zealand white rabbits, aged 5-6 weeks, were analyzed in 4 groups. The groups; I. Control (basal diet), II. SC (added 3 g/kg diet), III. SP (added 5% of the diet), IV. SC and SP (added 3 g/kg SC and 5% SP of the diet),  respectively. The entire experiment lasted 90 days. Blood samples were obtained by ear venipuncture on the 90th day. The CD4+ and CD8+ T lymphocyte values were  determined by flow cytometry and cytokines (IFN-γ and IL-4) were determined by ELISA. According the results, there were no significant differences occurred in the expression of cytokines, but serum CD4+/CD8+ increased in the animals fed SP and SC+SP supplemented diets (3 g/kg and 5% of the diet, respectively). So, S. platensis may be used as an immune enhancer. All the same, more studies would be necessary to clarify the effects of supplementing spirulina on immunity.
Published
Sep 15, 2017
How to Cite
SEYIDOGLU, Nilay et al. The Effects Of Spirulina platensis And Saccharomyces cerevisiae On The Distribution and Cytokine Production Of CD4+ And CD8+ T-Lymphocytes In Rabbits. Austral Journal of Veterinary Sciences, [S.l.], v. 49, n. 3, p. 185-190, sep. 2017. ISSN 0719-8132. Available at: <http://australjvs.cl/index.php/amv/article/view/601>. Date accessed: 27 feb. 2021.
Section
Original Article